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Principles of early drug discovery

Regarding feeding behavior, 3xTg mice consume more food with a rise in metabolic rate as compared to non-transgenic controls (Romberg et al., 2011)

We found that the administration of Nrf2 activators could improve autism-like symptoms and molecular alterations in ASD by against inflammation/immune dysfunction, oxidative stress, and mitochondrial dysfunction

Structural visualization, image processing, and analysis of docking results were performed using PyMOL 2.5.2

While the classical Warburg effect highlights glycolysis as the primary metabolic pathway in cancer, a growing body of evidence demonstrates that mitochondrial function is equally indispensable, especially under therapeutic stress and in metastatic contexts