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The research doesnt give a physiological explanation for the results, but Silverstein says that since nicotine and smoking harm the vascular system, the findings suggest they also damage blood vessels and neurons in the retina

Next they connected these joints to a smoke cycle simulator machine that uniformly inhaled six times for three seconds each, then exhaled. Filters collected the aerosols at the machines 3-D-printed mouthpiece, and the researchers used analytical chemistry techniques to measure aerosol levels from puffs taken at the beginning, middle, and end of each joint