tobacco vasoconstriction Nicotine can shrink blood vessels, which restricts the flow of crucial nutrients. Over time, cells degenerate or die, which impacts spinal cushions and breaks down the vertebral discs. This process Cardiovascular Toxicity of Nicotine: Implications

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This gives it its characteristic demulcent (agent that soothes and relieves irritation in mucosal membranes) properties (13)