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Description

In the original 2015 Cell Metabolism paper, MOTS-c activated AMPK, improved insulin sensitivity in diet-induced obese mice, and reduced age-related insulin resistance in older animals [2]

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In lipodystrophy, patients lack adipose tissue due to genetic mutations in the ability to properly form functional adipocytes or to store FAs as TAGs (168)

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In addition, it highlights how these insights inform experimental design and interpretation in metabolic research

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