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Beyond gastrointestinal effects, clinical data and class-level evidence from licensed incretin agents (semaglutide, tirzepatide) have flagged concerns regarding: Heart rate elevation: Increases in resting heart rate are a recognised class effect of GLP-1 receptor agonists, documented in the SmPCs for semaglutide (Wegovy) and tirzepatide (Mounjaro)
Splitting daily doses into two administrations (morning and evening) maintains more consistent circulating levels
doi:10.1152/japplphysiol.00945.2010 Staresinic M, Sebecic B, Patrlj L, et al
Injectable vials are typically used subcutaneously or intramuscularly, and proper sterile technique should be followed to ensure safety and minimize the risk of infection
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