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While side effects are generally minor and infrequent, these may include allergic reactions, diarrhea, vomiting, and nausea

This argument is plausible it reflects a well-documented problem in drug development where unpatentable compounds struggle to attract industry funding regardless of their scientific merit but it should be noted that this explanation, while widely discussed, has not been formally established in the published literature as the primary reason for the evidence gap

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Tardivo, J

The activation of sirtuins, proteins strongly associated with longevity, provides additional anti-aging benefits