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Interestingly, PHGDH also affects tumor biology independently of its effects in serine metabolism, for example, directly interacting with the RNA-binding protein Poly(rC)-binding protein 2 (PCBP2), and inhibiting its proteasomal degradation

For example, specific gene polymorphisms have been linked to variations in depressive symptoms in response to major life stress, underscoring the important role genetic factors play in the disorders pathogenesis [302, 303]