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The misuse-abuse of fentanyl causes adverse effects including opioid-induced respiratory depression (OIRD) 1

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and lipid peroxides to their corresponding alcohols mainly in the mitochondria and sometimes in the cytosol.39 Most times, its activity depends on a micronutrient cofactor known as selenium

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After 8 days of acquisition training, a 9th day of trials commenced where the platform was taken away from the apparatus and the rats had to swim for a full 120 seconds while the research team recorded how many times each rat passed into the quadrant where the platform was previously located