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Conversely, overcoming the blood-brain barrier, nanoparticle toxicity, and patient variability still remain as some of the obstacles that require further research

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Kava-kava Extract WS 1490 versus Placebo in Anxiety DisordersA Randomized Placebo-controlled 25-week Outpatient Trial

Large randomized controlled trials

Singh et al., 2020), increasing susceptibility to post viral fatigue syndrome, LC, CFS, POTS (Blitshteyn et alo., 2017), and some MTHFR variants (Okamoto et al., 2012)