A low ratio might suggest that your body is using up its antioxidant stores faster than it can replenish them
It has also been reported that secretogranin II (known as chromogranin C), is a potent chemoattractant for eosinophils [220], which play a critical role in asthma [221]
However, not all of the gene responses in the cells expressing IR L973F showed the same pattern as those in chimeric receptors
For the latter, although FDA-approved sorafenib and salazosulfapyridine have been shown to induce ferroptosis through this pathway, tumor cells can compensate for cysteine and GSH through the SLC7A11 protein, ASC transporter system, and thiol antioxidants, resulting in limited therapeutic effects
Crucially, the context-dependent role of regulatory pathways like Nrf2 highlights the complexity of therapeutic targeting