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Ligand-mediated dimerization of the Met receptor tyrosine kinase by the bacterial invasion protein InlB

TS inhibition by 5FU regulates mitochondrial biogenesis through mTORPGC1 signalling 5FU has a multimodal mechanism of action: promoting DNA damage directly via its metabolite FdUTP or by inhibition of TS via FdUMP, depleting the pool of thymidine available for DNA synthesis, and causing RNA damage via FUTP (Fig

Crotonoside, a key constituent of Crotonus sativus listed in the Chinese Pharmacopoeia, induces ferroptosis in AML cells by stimulating lipid peroxidation and increasing autophagy, offering a novel approach for AML treatment (164)

Briefly, cells were treated with 100 M BSO (dissolved in culture medium) for 18 h and washed with fresh serum free DMEM followed by aspirin treatment as above

For example, phenobarbital induces UGT1A1 activity, enhancing bilirubin conjugation under positive scientific situations [31]