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According to a study published in the Journal of Cancer Science and Therapy (2), glutathione shortage increases oxidative stress, which can lead to cancer

In Vitro 18, 231243 (2004)

Free Radic Biol Med 27:922935

Skin conditions : Conditions like eczema or psoriasis can contribute to dark spots

However, it had similar temporal pattern, and this activation was prevented by K252a kinase inhibitor and corresponding MEK1 and PI3 kinase inhibitors (PD98059 and LY294002 respectively)