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Persistent DNA damage leads to the formation of chromatin-modifying segments known as DNA segments with chromatin alterations reinforcing senescence (DNA-SCARS) [18]

Hence, necrotic liver and the opening of the mitochondrial membrane permeability transition (MPT) hole are caused by ROS formation 11,12

Because composite antioxidant assays reflect extracellular antioxidant pools and are influenced by multiple circulating factors beyond glutathione, future studies should incorporate functional endpoints alongside PK and expanded sulfur-metabolism panels to clarify physiological relevance and optimal dosing

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