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doi: 10.31557/APJCP.2024.25.7.2271 106 JinBWanSBoahMYangJMaWLvMet al

3 Ferroptosis in RCC 3.1 Ferroptosis signaling pathway and RCC 3.1.1 HIF-iron metabolism pathway involved in ferroptosis and RCC ccRCC is associated closely with mutations in the VHL gene that lead to the activation of HIF-1 and HIF-2 via a pseudohypoxia mechanism, resulting in the transcription of genes involved in tumor progression ( 3.1.2 Ferroptosis-related lipid metabolism and RCC The acyl-CoA synthetase family member ACLS3 not only regulates the accumulation of lipid droplets in ccRCC and is essential for tumor growth, but also regulates sensitivity to ferroptosis in a manner dependent on the composition of exogenous fatty acids: both functions are implicated in the treatment of ccRCC ( 3.1.3 GSH/GPX4 pathway and RCC The System X c /GSH/GPX4 axis is involved in ferroptosis inhibition ( Inactivating mutations of KDM5C, commonly found in patients with ccRCC, alter glycogen metabolism, leading to increased NADPH and GSH levels and thereby inhibiting ferroptosis

Epigenetic mechanisms in diabetic vascular complications

It can slow or stop loss and sometimes regrow miniaturised hair, especially with minoxidil