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12,13 The criteria included the following: Apoptosis or necrosis Degeneration of hepatocytes Hepatic sinusoids, central vein (dilatation or congestion) Inflammatory cells Parenchyma architecture Scoring was as follows: = No changes watched

Studies have also indicated interactions with opioid pathways DSIP administration has been shown to modulate pain perception and has effects that can be partially blocked by opioid antagonists in some paradigms, suggesting opioidergic involvement in at least some of its actions

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