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however, the largest cluster included only two mice from the 5A-1MQ-treated group switched from WD to LD

Sohn JH, Han K-L, Lee S-H, Hwang J-K

The compound also decreased the activity of stress-induced kinases (SAPK/JNK and pERK1/2), suggesting additional neuroprotective mechanisms beyond simple neurotrophin upregulation

These clues underscore the need for multidisciplinary approaches to advance our understanding of angiogenesis in neurodegeneration and to develop therapeutic strategies that optimize efficacy while minimizing unintended consequences