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From these findings and the fact that glutathione is essential for lymphocyte proliferation and immune responses, , we hypothesized that abundant cystine/cysteine in the kidneys forms a unique metabolic microenvironment that supports ectopic lymphocyte proliferation, leading to the formation of TLS

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25 In brief, E17.5 embryos were removed from timed-pregnant mice, and metatarsals were dissected

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