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Since mouse microbiome profiles often highly correlate with body weight and fat composition, this study was designed to test whether the cecal microbiomes of DIO mice treated with NNMTi and LD were comparable to the microbiomes of age-matched lean counterparts and distinct from microbiomes of DIO mice maintained on a high-fat Western diet (WD) or subjected to LD switch alone

Scientific data suggests that the FOXO family of proteins may act downstream of insulin signaling to regulate cellular growth, metabolism, differentiation, and oxidative stress

There are interactions with the serotonin and GABA systems too, and some animal studies have shown anxiety-reducing effects