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Because probenecid affects the activities of several proximal tubule transporters it can also be used in conjunction with certain other drugs to inhibit their secretion and thus, increase their effective serum concentrations

That level of activity is almost unprecedented in neuropharmacology

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In the study above, the authors note that more drugs [from postauricular injection] concentrated in the inner ear for longer therapeutic time, and less systemic delivery implied less risk of side effects. Practical Considerations: Injection Scheduling Protocol typically involves multiple injections over 12 weeks

Te Braake, F