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In the case of bones, aging is associated with increased activity of osteoclasts, cells that break down bone tissue

Naunyn Schmiedebergs Arch Pharmacol 2024, 397: 81898209

Targeting ferroptosis in bone-related diseases: facts and perspectives

Stressed and injured NASH hepatocytes express and secrete a second Hedgehog ligand, Sonic Hedgehog (SHH), which is positively correlated with hepatocyte ballooning, steatosis, pericellular fibrosis, and fibrosis stage in liver samples from NASH patients (206, 207)