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5,145 Many recently identified genes, including (human clinical study) the aldose reductase (AKR1B1) gene, VEGF,5,10, methylenetetrahydrofolate reductase (MTHFR) enzyme variants, APOE, and angiotensin-converting enzyme (ACE) genes, play important roles in the polyol pathway, vascular endothelial cell value-addition, and oxidative stress in endothelial cells induced by hyperhomocysteinemia

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But, even after all of that, many of my symptoms persisted until I began piecing together my histamine intolerance and mast cell activation story