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DEFENSE AGAINST ELECTROPHILES AND PROTEIN GLUTATHIONYLATION In addition to the defense against oxidants and ROS, GSH plays also an important role in the protection against electrophiles by glutathione- S -transferases (GSTs)

Inhibition of the neuronal NFB pathway attenuates bortezomib-induced neuropathy in a mouse model

Current Pharmaceutical Design , 19 (1), 7683

Notably, LBs have also been observed in several other neurological disorders, including dementia with Lewy bodies, the LB variant of Alzheimers disease, infantile neuroaxonal dystrophy, HallervordenSpatz syndrome, subacute sclerosing panencephalitis, and Down syndrome

The translational diversity of HAGSH scaffold systems across various functional designs and therapeutic outcomes is summarized in Table2