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doi: 10.1146/annurev-med-051223-031809 43 MinodaHSakaiJSugiuraMImaiSOsatoTUsuiM

Another consideration is the interplay of BPC 157 with lifestyle improvements

Caffeine prevented lipid peroxidation, as evidenced by increased MDA levels [33, 34, 42], increased antioxidant factors such as SOD and glutathione peroxidase (GSH) [34, 38, 42], reduced acetylcholinesterase activity [37], increased BDNF levels [33, 40] and neurogenesis by reducing p-MEK/MEK, p-ERK1/2/ERK 1/2 e p-NFkB/GPADH ratios [39, 40], neuroprotection measured by KA/3-HK and KA/KYN ratios [32] and restore gut microbiota balance [38]

24 This opens the door to exploring these novel compounds as potential therapeutic agents in a broader range of conditions

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