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The clinical features include redundant, sagging, fragile skin, delayed closure of the fontanelles, blue sclerae, umbilical hernia and short stature.24 Most patients have a very severe phenotype presenting at birth, but some have milder manifestations.25 Electron microscopy of skin shows characteristic hieroglyphic fibrils.26 The diagnosis is confirmed through genetic testing of ADAMTS2

The trend has concerned scientists at the FDA, who have repeatedly questioned the evidence behind many peptides