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Selective inhibition of NAPRT can modulate NAD + levels, providing therapeutic benefits in cancer treatment and neuroprotection 227,228

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Hydrogenation was completed using the AutoDock (version 1.5.7), and the molecular docking processes were achieved through AutoDock Vina (version 1.2.5) with the grid boxes parameters (Table S2)

The active site is located in a cleft situated between domains I and II and each subunit binds two molecules of a competitive inhibitor S-hexylglutathione

Glutathione is generally well-tolerated, but some individuals may experience mild gastrointestinal issues or skin flushing