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These alterations collectively impair Nrf2-driven antioxidant and anti-inflammatory responses, resulting in diminished expression of downstream protective enzymes such as HO-1 and GSH ( BL has been shown to promote nuclear translocation of Nrf2, thereby upregulating HO-1 and enhancing the production of key antioxidant enzymes, including GSH, superoxide dismutase (SOD), and NAD(P)H quinone oxidoreductase 1 (NQO1) ( 2 O 2 exposure, compared with controls (Zhao et al., 2024)

10.1016/j.molbiopara.2005.09.001 117 KumaA.KomatsuM.MizushimaN

In addition, motilin lacks fatty acid modifications, making it incapable of binding to the ghrelin receptor

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