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It is supposed that APAP would inhibit the synthesis of prostaglandins comprising a COX site (active site of the majority of NSAIDs 12 ) in the central nervous system, prostaglandins having a pro-nociceptive role and potentially causing fever in the hypothalamus on which APAP would act 13

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The use of dietary supplements can therefore prove very beneficial in enabling the body to withstand multiple external aggressions

Pharm Res 30:21742187 McGill MR, Jaeschke H (2014) Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients