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Peptides containing methionine residues are prone to oxidation because methionine readily converts to methionine sulfoxide when exposed to oxygen

10.1016/j.joca.2014.11.004 Osteoarthritis Cartilage 16 CarrH

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Mechanistically, metformin inhibited PKCII membrane translocation and NADPH oxidase activation in neutrophils, thereby lowering the activation threshold for NETosis [94]