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Genetic variations or polymorphisms in cytochrome P450 metabolism may also be responsible for unusual sensitivity or resistance to drug effects at normal doses among different individuals [27]

The average mortality rate is 4% to 10% from multiorgan failure (most commonly hepatic necrosis), 22 with long-term complications that include exfoliative dermatitis, 23 acute necrotizing eosinophilic myocarditis, and autoimmune sequelae such as thyroid disease, vitiligo, alopecia areata, lupus erythematosus, autoimmune hemolytic anemia, and fulminant type 1 diabetes mellitus

Patients on blood thinners should inform Dr

Crizotinib shows its inhibitory effects towards c-MET and ALK by binding to the activation loop and stabilizing the autoinhibitory conformation of each kinase

A possible peroxidative role for paraoxonase