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doi: 10.1073/pnas.91.11.5104

Cyanocobalamin can lead to optic nerve damage and possibly blindness in people with Lebers disease

Following that, the frequency changes based on your response

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Trends in adult body-mass index in 200 countries from 1975 to 2014: A pooled analysis of 1698 population-based measurement studies with 192 million participants (in Eng)