Other interesting observations come from primary sclerosing cholangitis: specific strains of Klebsiella pneumonia detected in these patients could damage gut barrier integrity, favoring bacterial translocation of other pathobionts toward the mesenteric lymph nodes, and prime a TH17 cell response in the liver, if transplanted into mice models [46]
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Discontinue use if redness, itching, or irritation occurs during or after application, especially after sun exposure
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In a controlled colesevelam trial in 30 patients with IBS-D, colesevelam did not alter mucosal permeability (179)
