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Chronic viral infections can drive this up over 40 percent or in some cases down below 20 percent

When the barrier is damaged, epithelial cells can secrete cytokines (such as IL-8, TNF - ), recruit immune cells (such as neutrophils, macrophages) to clear pathogens, and repair the barrier damage

Another focus is on specifically targeting renal cells, especially glomerular cells, and considering alternatives such as avoiding the reticuloendothelial system [76]