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The metabolite subsequently binds covalently to cellular proteins, leading to oxidative stress, mitochondrial dysfunction, and ultimately hepatocellular necrosis 37,38,39

AMPK: Sensing Glucose as well as Cellular Energy Status

[11] To avoid this, always ensure that the final admixture is approximately isotonic, typically achieved by the drug or other diluents added to the bacteriostatic water, before injecting into the bloodstream