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Because, in excitatory neurons, spines are considered as the morphological substrate for restricting the spread of synaptically induced [Ca 2+ ] i rises, thus restricting plasticity to the activated synapses, it was proposed that, in aspiny dendrites, input-specificity of plastic changes might be compromised

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Treatment Supportive therapy includes rehydration and, if possible, discontinuation of treatment with the offending antibiotic

SIRT1 is a deacetylase that epigenetically influences the expression of a wide variety of genes, including the gene for LC3

This cohort, known as the Taxonomy cohort 38 , comprised 156 stage II or stage III patients, 66 (35 male, 31 female) of whom went on to receive adjuvant 5FU-based chemotherapy (illustrated in Fig