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Additionally, repeated freeze-thaw cycles are particularly damaging to metal-peptide complexes because the copper(II) ion can catalyze oxidative damage to the histidine imidazole ring during the transient concentration spikes that occur at ice-liquid interfaces

Maniatis, N

OGC imports cytosolic GSH into mitochondria in exchange for 2-oxoglutarate (2-OG) and other dicarboxylates

Regular intake contributes to ensuring that key nutrients are efficiently absorbed

Sustained UPR activation not only promotes the production of inflammatory mediators as previously described, multiple studies have also reported its association with cellular senescence (53)