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Lentivirus vectors: difficulties and hopes before clinical trials

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Inspired by intracellular multi-enzyme cascade reactions, researchers initially attempted to construct artificial cascade systems by encapsulating natural enzymes within porous synthetic materials, including metal-organic frameworks (MOFs), covalent organic frameworks (COFs), and hydrogen-bonded organic frameworks (HOFs) (Lykourinou et al., 2011

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aureus camSOD (Figure 32A) allows superoxide detoxification during host-imposed Mn starvation by calprotectin (CP), which functions in place of the Mn-dependent SodA (Figure 32B) and is presumably not effectively metalated under these conditions (Section 2.2.2)