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The effect of glutamine administration on GSH levels has also been evaluated in a 5-fluorouracil-induced model of liver injury

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Discussing glutathione treatment safety means examining its effects on the body when dealing with these concentrated amounts

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This distinction is relevant when considering mitophagy-oriented strategies, because beneficial effects observed after suppression of downstream inflammatory mediators do not by themselves establish that direct augmentation of mitophagy in PACs would remain advantageous under all pathological conditions