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This was associated with substantive mobility of the RAMP2 linker and TM helix, which had weaker interaction with the CTR TM bundle compared to RAMP1 and RAMP3 in AMY 1 R and AMY 3 R complexes

Clinical Biochemistry

M., Kalogjera, L., Vranes, H., Sola, M., Strbe, S., Koprivanac, A., Premuzic Mestrovic, I., & Mestrovic, T

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Both mouse and human FcRIIBs contain an intracellular immunoreceptor tyrosine-based inhibitory motif signaling domain and are considered to be inhibitory, whereas all other murine and human FcRs transduce an activating signal via an immunoreceptor tyrosine-based activation motif (ITAM)