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In this context, H3K18la has been demonstrated to enhance the transcription of YTHDF2

J Crit Care 26(2):225

10.3389/fendo.2018.00802 357 ZhangX.ZhaoQ

By screening small fragment-sized molecules (typically 120250 Da), chemical space can be effectively sampled using a substantially smaller number of compounds than through typical high-throughput screens (HTS) with bigger, lead-like molecules

Regarding macrophage senescence and cell death, ATF4 is identified as the core responder to hypoxic stress and it rapidly accumulates in macrophage nuclei within 1-h of hypoxic challenge to activate adaptive gene networks to sustain cell viability (137)