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[PubMed] 35.Perishable A, Advisory

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Severe allergic reactions, persistent edema, or signs of high IGF-1 (joint pain, carpal tunnel, headaches) warrant clinical review

This has recently been used to shuttle the entire and fully functional enzymes to the brain and into subcellular compartments using the transferrin receptor: the enzyme -glucocerebrosidase coupled to TfR-binding moieties and the amyloid-beta antibody gantenerumab fused also with the TfR-binding moieties have been successfully transferred to the brains of mice and non-human primates [319, 320]