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L-carnitine is a non-essential amino-acid-like compound, responsible for transporting long-chain fatty acids to your cells' mitochondria, where energy is produced from the fat's oxidation

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The direct use of protein neurotrophic factors such as HGF as therapeutic agents has two serious limitations: 1) large size and hydrophilic character precludes BBB permeability

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doi: 10.1111/j.1467-789X.2012.01041.x