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Therefore, this article provides a review of the mechanism of Nrf2 in RA and summarizes natural products that target Nrf2 and its associated pathways in the treatment of RA, aiming to offer new insights and strategies for the prevention and management of RA

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Dihexa (chemical name N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, development code PNB-0408) is a synthetic peptide derived from angiotensin IV, originally developed by researchers at Washington State University as a potential therapy for Alzheimer's disease