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Rodrigues et al., 2019) and the likely role of taurine in the regulation of network excitability in the immature neocortex and hippocampus ( Caffeine is an antagonist at A 1 and A 2A adenosine receptors and thus by binding to adenosine receptors can increase the release of various neurotransmitters (glutamate, serotonin, acetylcholine, noradrenaline, dopamine) (McLellan et al., 2016) and, at high concentrations, it is also able to inhibit phosphodiesterase thereby modulating intracellular cyclic adenosine monophosphate and intracellular calcium in brain (Rodrigues et al., 2019)