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The recombinant CPP-SOD fusion protein, which combines the SOD protein with short cell-penetrating peptides (CPPs) (Table 1), can cross the BBB and alleviate severe oxidative damage in various brain tissues by scavenging reactive oxygen species, reducing the expression of inflammatory factors, and inhibiting NF-B/MAPK signaling pathways [61]

FIGURE 2 Nrf2 regulates ferroptosis in many ways, and the relationship between Nrf2 and the key pathways for ferroptosis regulation has already attracted attention (Table 1)

But there are important caveats to the findings, and thyroid disease and psoriasis appear to be impacted

References Mikelsaar M, Zilmer M

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