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The ethical principles of the study are in accordance with the European Directive 010/63/E, the Act on Amendments to the Animal Protection Act (Official Gazette 37/13), the Animal Protection Act (Official Gazette 135/06), the Ordinance on the Protection of Animals Used for Scientific Purposes (Official Gazette 55/13), the recommendations of the Federation of European Laboratory Associations for Animal Science (FELASA), and the recommendations of the Ethics Committee of the Faculty of Medicine, University of Zagreb

The expiration date depends on manufacturing conditions, not vial size

Reconstituted semaglutide from PlexusDx licensed 503A compounding pharmacies remains stable for up to 28 days when stored in a refrigerator at 36-46F

Heffernan 2001b No antibody formation or immunogenic response detected across trials

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