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83 Moreover, H4K12la in PC9-BrM3 cells facilitates CCNB1 transcriptional activation, which accelerates DNA replication and the cell cycle, promoting acquired resistance to pemetrexed in lung cancer-derived brain metastasis

While Abs have an excellent safety profile compared with other therapeutic classes, there are cases where their specific targeting go awry

The Ussing chamber technique is often utilised in animal studies where intestinal tissues may be obtained following sacrifice of the animals [41, 42] and in human studies of intestinal diseases where endoscopic biopsy samples may be obtained [43]

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