Antioxid Redox Signal 7:10531061 Gedlicka C, Kornek GV, Schmid K, Scheithauer W (2003) Amelioration of docetaxel/cisplatin induced polyneuropathy by alpha-lipoic acid
Rittig, N
The authors show that these isoforms are differentially expressed across tissues and hypoxic conditions, indicating context-dependent functions ( HIF-1, also known as the aryl hydrocarbon receptor nuclear translocator (ARNT), is the obligate heterodimerization partner for all HIF- subunits and is indispensable for hypoxia-mediated transcriptional responses ( Beyond its canonical role in hypoxia signaling, HIF-1 integrates hypoxic responses with other environmental and metabolic signaling pathways ( Although HIF-1 itself is not oxygen-regulated, alterations in its expression levels, post-translational modifications, or subcellular localization can significantly modulate hypoxia-driven tumor biology ( 3 Hypoxia-driven metabolic reprogramming 3.1 Glycolytic shift: the Warburg effect A hallmark of hypoxia-induced metabolic adaptation in cancer cells is the preferential use of glycolysis over oxidative phosphorylation (OXPHOS), even when oxygen is sufficiently availablea phenomenon known as the Warburg effect ( PGC-1 and TFAM , as well as those encoding components of the electron transport chain
Maintains a controlled pH of 5.7, within an acceptable range of 4.5 to 7.0, to support consistency across research applications
(9) Mondelli M, Passero S, Giannini F
