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These considerations likely contribute to discrepancies in sulforaphane preclinical trials (Table 1)

15-LOX and its oxygenation products affect cellular function by modifying biomembrane structure, and 15-LOX has a dual effect on the inflammatory response

TB-500 also exhibits clinically relevant anti-inflammatory properties through downregulation of inflammatory cytokines including TNF- and IL-1

It has been demonstrated that AS-IV reduces ROS and Fe 2+ levels while promoting the expressions of GPX4 and SLC7A11 in OGD/R-injured HUVECs, thereby effectively restraining ferroptosis in I/R-AKI