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The authors of one trial (95) included in the above-mentioned meta-analysis (89) noted that little cognitive decline was observed in the placebo group over their two-year trial, which may have limited their power to detect an effect of the B-vitamin intervention (95)

In turn, these investigations support broader research into how compounds interact with systems involved in metabolic regulation

They have demonstrated efficacy in alleviating pain associated with diabetic neuropathy, neuralgia, and low back pain, as well as promoting nerve conduction, making them beneficial for a variety of neurological and pain-related conditions

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