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The main targets of the predicted drugs and our list of predicted essential genes had a higher median dependency probability (likelihood that the knock-out of a gene reduces cell growth or induces cell death) than targets of known anti-melanoma drugs (Fig

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We found a significant lower SDF in patients on AOX compared to controls when the analysis was repeated after the exclusion of one study carried out in patients treated with varicocele repair and AOX or placebo/no treatment [29] (SMD -1.47 [95% CI: -2.18, -0.77]

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